Ipapashwe ngu: West China School of Pharmacy University Sichuan

Umxholo oyintloko: Unyango olusebenzayo lwe-Alzheimer's disease (AD) luthintelwe ngokungena kwe-blood-brain barrier kunye nokusabalalisa okungakhethiyo kweziyobisi kwingqondo.Ukongezelela, iindlela ze-pathological ze-AD zinzima kwaye zibandakanya ukungasebenzi kweendlela ezininzi, ukunciphisa ukusebenza kwe-agent eyodwa yonyango.Eli nqaku liyila i-DGL-based siRNA kunye ne-D-peptide (Dp) -ilayishwe i-nanoparticles, enokuthi ijolise kwaye ingene kumqobo wegazi-ingqondo, ingene kwi-brain parenchyma, kwaye iqokelele ngakumbi kwizilonda ze-AD, ukuphucula ukusebenza kakuhle kokungena kweziyobisi kwingqondo, ukuphucula ukungasebenzi kwengqondo kunye nomonakalo we-neuronal obangelwa yi-AD.Funda ngokugqithisileyo

Ipapashwe ngu: West China School of Pharmacy University Sichuan

Umxholo ophambili: I-hypoxic microenvironment yamathumba aqinileyo yimpembelelo ebalulekileyo ye-metastasis yomhlaza.Ke ngoko, ukuphucula i-hypoxia kwindawo ye-tumor yindlela esebenzayo yokuthintela i-tumor metastasis.Xa kuthelekiswa nokubulala ngokuthe ngqo iiseli zethumba, ukulungiswa kwe-tumor microenvironment kunokuthintela ukwenzeka kunye nophuhliso lwamathumba kwiinkalo ezininzi, eyona ndlela yonyango enokubakho kakhulu.Olu phononongo lwenze umthwali onamandla okuhamba ngokuzimeleyo kwaye angakwazi ukuvelisa ioksijini enzulu kwithumba.Kwangelo xesha, okokuqala, isicwangciso esidityanisiweyo sokuphucula i-hypoxia kunye nokuthintela i-glycolysis yacetywa ukuba iguqule ngokupheleleyo i-tumor microenvironment kwaye ifezekise isiphumo sokuthintela i-metastasis yomhlaza wamabele.Funda ngokugqithisileyo

Ipapashwe yi: College of Life Sciences IYunivesithi yaseSichuan

Umxholo oyintloko: I-abscisic acid (ABA) indlela yokubonisa ibandakanyeka kwiimpendulo zezityalo kwisomiso kunye noxinzelelo lwetyuwa.Nangona indlela yokubonisa i-ABA iye yacaciswa kwi-Arabidopsis, ihlala ingafunyanwanga kwi-poplar yomthi.Kule sifundo, uhlalutyo lwe-genome-wide-wide ye-poplar U-box genes lubonise ukuba i-U-box E3 ubiquitin ligase gene PalPUB79 yakhuthazwa kakhulu emva kwembalela, usawoti kunye ne-ABA yokubonisa.Iziphumo zibonise ukuba i-PalPUB79 ilawula ngokufanelekileyo indlela yokubonisa i-ABA, inika ulwazi olutsha kwindlela apho i-PalPUB79 iphucula iimpendulo ze-ABA-mediated stress kwi-poplar yomthi.Funda ngokugqithisileyo

INFO yemveliso

Ixesha lokwenyani PCR Easyᵀᴹ-SYBR Green I Kit

I-REF: QP-01012/QP-01014