“Iziyobisi zeNucleic acid” zisebenzisa i-“nucleic acid,” ebhekisela kwizinto ezinjengeDNA neRNA elawula inkcazelo yemfuza, njengamachiza.Oku kuvumela ukujoliswa kweemolekyuli ezinjenge-mRNA kunye ne-miRNA ezingenakujoliswa kumachiza esintu anobunzima obuphantsi bemolekyuli kunye namachiza e-antibody, kwaye kukho ulindelo olukhulu kula machiza njengamayeza esizukulwana esilandelayo.Uphando olusebenzayo lwenziwa kwihlabathi jikelele njengoko kulindeleke ukuba lukhokele ekudalweni kwamachiza ebekade enganyangeki.
Ngakolunye uhlangothi, kuye kwaphawulwa ukuba ukuphuhliswa kweziyobisi ze-nucleic acid kunemiba yokuphumelela, kubandakanywa "(i) ukungazinzi kwe-nucleic acid molecules emzimbeni," "(ii) iinkxalabo zokusabela kakubi kweziyobisi," kunye "(iii) nobunzima kwinkqubo yokuhanjiswa kweziyobisi (DDS)."Kwakhona, iinkampani zaseJapan ngamanyathelo ngasemva kuphuhliso lwamachiza e-nucleic acid ngenxa yokulawulwa kwamalungelo awodwa abenzi be-nucleic acid ziinkampani zaseYurophu nase-US, ezibangela ukuphazamiseka kuphuhliso lwaseJapan.
Iimpawu zeziyobisi ze-nucleic acid
"Iziyobisi ze-Nucleic acid" sisizukulwana esilandelayo sokufumana iteknoloji yokufumanisa iziyobisi kunye nenkqubo yokusebenza eyahlukileyo ngokupheleleyo kuneemveliso zamayeza zendabuko.Ikwanesakhono sokwenziwa ngokulula kwiimolekyuli ezinobungakanani obuphakathi kunye nokubanakho ukubonisa ukusebenza kakuhle kunye nokhuseleko oludlula ezo zamachiza e-antibody.Ngenxa yezi mpawu, kukho ulindelo lokuba amachiza e-nucleic acid asetyenziswe kumhlaza kunye nokuphazamiseka kwemfuza ebekunzima ukuyinyanga ngaphambili, nakwizigulo ezinjengomkhuhlane kunye nosulelo lwentsholongwane.
Iintlobo zeziyobisi ze-nucleic acid
Ichiza le-Nucleic acid elisebenzisa i-DNA kunye ne-RNA libandakanya ezo zijolise kwi-nucleic acid kwinqanaba apho iprotheyini yenziwe i-genome DNA (efana ne-mRNA kunye ne-miRNA) kunye nezo zijolise kwiprotheni.
Iintlobo kunye neempawu zeziyobisi ze-nucleic acid (iziyobisi ze-prophylaxis kunye nonyango)
Kukho iziyobisi ze-nucleic acid ezineentlobo ezahlukeneyo kunye neempawu ngokweethagethi kunye neendlela zokwenza.
| Uhlobo | Ekujoliswe kuko | Indawo yokwenza | Indlela yokwenza | Isishwankathelo |
| siRNA | mRNA | Ngaphakathi kwiseli (cytoplasm) | Ukususwa kwe-mRNA | I-RNA ephindwe kabini kunye nokucandeka kwe-mRNA i-homologous kwiukulandelelana (i-siRNA), i-hairpin ene-single-stranded RNA (shRNA), njl.ngesiphumo ngokomgaqo we-RNAi |
| miRNA | microRNA | Ngaphakathi kwiseli (cytoplasm) | Ukutshintshwa kwe-microRNA | I-RNA ephindwe kabini, i-miRNA ye-hairpin enemisonto enye ye-RNAokanye ukulinganisa kwayo kusetyenziselwa ukomeleza umsebenzi we-miRNA wonakelengokuphazamiseka |
| I-Antisense | mRNA miRNA | Ngaphakathi kwiseli (kwinucleus, cytoplasm) | Ukuthotywa kwe-mRNA kunye ne-miRNA, ukunqanda ukuqhekeka | I-RNA/DNA enomtya omnye obophelela kwi-mRNA ekujoliswe kuyokunye ne-miRNA ukubangela ukuthotywa okanye ukuthintela,okanye yenza ukutsiba i-exon xa udibanisa |
| Isixhobo | Iprotheyini (iprotheni engaphandle kweseli) | Ngaphandle kwesisele | Isithintelo esisebenzayo | I-RNA/DNA enemisonto enye ebophelela kwiprotheyini ekujoliswe kuyongendlela efanayo kwii-antibodies/DNA |
| Ukuqhatha | Iprotheyini (i-transcription factor) | Ngaphakathi kwiseli (kwinucleus) | Uthintelo lokukhutshelwa | I-DNA ephindwe kabini ngokulandelelana okufanayo kwindawo yokubophayoshicilelo, olubophelela kushicileloyejini echaphazelekayo ukucinezela ijini ekujoliswe kuyo |
| Ribozyme | I-RNA | Ngaphakathi kwiseli (cytoplasm) | Ukuqhekeka kwe-RNA | I-RNA enemisonto enye enomsebenzi we-enzyme yokubopha kunye nokuqhekekayeRNA ekujoliswe kuyo |
| CpG oligo | Iprotheyini (i-receptor) | Umphezulu weseli | Immunopotentiation | I-Oligodeoxynucleotide ene-CpG motif (i-DNA enemisonto enye) |
| Okunye | - | - | - | Nucleic acid ichizas ngaphandle kwezo zidweliswe ngasentla azenzayovula ukugonyeka kwemvelo, okufana nePolyI:PolyC (i-RNA enemisonto ephindwe kabini)kunye ne-antigen |
Ixesha lokuposa: Jul-25-2023
