Ngokwezibalo ze-Zhiliwo Big Data Platform, i-avareji yempembelelo yempembelelo yokucaphula amaphepha e-Foregene SCI ngoFebruwari 2022 iphezulu njenge-5.8, kwaye impembelelo ephezulu ye-8.947.
Ngohlalutyo lwamanani amanani ee-SCI zeemveliso ze-Foregene kwiminyaka edlulileyo, kufunyaniswa ukuba ukukhula kuyabonakala.
I-Foregene Co., Ltd. yasekwa ngo-2011. Lishishini le-biotechnology elidibanisa i-R&D, imveliso, intengiso kunye nenkonzo yabathengi.Ukusukela ekusekweni kwayo, ibigxile kuphuhliso lwetekhnoloji enxulumene nemolekyuli kunye neeseli zebhayoloji, iimveliso kunye neenkonzo, kwaye ibonelele ngokucocwa kwe-nucleic acid, ubhaqo lwe-nucleic acid kunye nezinye izisombululo kuninzi lwabasebenzisi.Umgca wayo wemveliso yophando lwezenzululwazi uquka uchungechunge lwe-RNA yokuhlanjululwa, uchungechunge lwe-DNA lokuhlanjululwa, uchungechunge lwe-RT / RT-PCR, uchungechunge lwe-PCR oluthe ngqo, uchungechunge lwe-PCR Mix, uchungechunge oluthe ngqo lwe-RT-qPCR kunye ne-"Sui" yezixhobo ezinxulumene ne-molecular.Iimveliso zisetyenziswe ngokubanzi kuphando olusisiseko kwiinkalo zenzululwazi yobomi, amayeza, ezolimo, amayeza, kunye nokusingqongileyo.Abathengi bahlala kwiiyunivesithi, kumaziko ophando, izibhedlele kunye nezinye iiyunithi.
U-ZhiLiaowo ukhethe amaxwebhu e-6 aphezulu aphezulu e-Foregene ngoFebruwari ukubhekisela kubaphandi, ukuze abe nokuqonda okunzulu kunye nokuqhelana neemveliso ze-Foregene.
Isihloko senqaku: Ukuqina kwe-Substrate kulawula ukwahlula kweeseli ze-pluripotent stem kwintliziyo yeeseli ze-endothelial
I-DOI: 10.1016/j.actbio.2022.02.032
Ixesha lokukhutshwa: 2022-2-27
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
Isihloko seNqaku: Ukuchonga iMitochondrial Proteome enokubakho iSiginitsha eDityaniswe nePathogenesis yePulmonary Arterial Hypertension kwiModeli yeRat
I-DOI: 10.1155/2022/8401924
Ixesha lokukhutshwa: 2022-2-21
Umbambiswano woMbhali: iSebe lezoKhemesti, iSibhedlele esiManyano nesokuqala seYunivesithi yezoNyango yaseXinjiang.
Abstract: I-pulmonary arterial hypertension (PAH) sisifo esimandundu nesiqhubekayo esichaphazela intliziyo nemiphunga kwaye yingxaki yezempilo yehlabathi echaphazela abantu kunye noluntu.Kule sifundo, imodeli yegundane ye-PAH eyenziwa yi-monocrotaline (MCT) yakhiwe ngempumelelo.Iiprotheyini ze-mitochondrial zeqela ngalinye leempuku zichongwe ngokusebenzisa i-label-free quantitative proteomic techniques.Ngokusekelwe kulwakhiwo kunye nokutyetyiswa okusebenzayo kweeprotheni-protein interaction (PPI) networks, i-19 up-regulated mitochondrial genes kunye ne-123 ye-mitochondrial ye-mitochondrial ephantsi yokulawulwa kwee-rats ze-PAH.Ukongezelela, kuvavanyo lwedatha yeqela elizimeleyo, iziphumo zibonise ukuba i-6 up-regulated mitochondrial genes kunye ne-3 ye-mitochondrial ephantsi-elawulwayo ibonakaliswe ngokuphawulekayo kwizicubu zemiphunga yeegundane ze-PAH.Ufuzo olusembindini lwemitochondrial olunokubakho lwe-miRNA luqikelelwe kwinqanaba le-transcriptome kusetyenziswa i-database ye-RNAInter.Uphononongo luphinde lwachonga i-bortezomib kunye ne-carfilzomib njengeziyobisi ezinokuthi zenze unyango lwe-PAH.Ekugqibeleni, olu phononongo lunika ukukhanya okutsha kwii-biomarkers eziphambili kunye nezicwangciso zonyango kwii-PAHs.
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
I-RT Easy II (I-Master Premix ye-First Strand cDNA Synthesis ye-qPCR)
Inombolo yekhathalogu: RT-01021
Inkcazo: 50 × 10 μL rxns
Isihloko senqaku: Ilahleko ye-PTEN inika ubuntununtunu kwi-rapalogs kwi-cell renal cell carcinoma ecacileyo
I-DOI: 10.1038/s41401-022-00862-1
Ixesha lokukhutshwa: 2022-2-14
Ubulungu boMbhali: iSebe leKhemesti, iSibhedlele saseNanfang, iYunivesithi yezoNyango yaseMzantsi, eGuangzhou, eChina
I-Rapalog yi-allosteric mTORC1 inhibitor kunye neyeza elivunyiweyo le-Advanced clear cell renal cell carcinoma (ccRCC).Uphononongo olusebenzisa imigca yeseli ye-ccRCC ephuma kwizigulana ezininzi lubonisa ukuba iiseli ezinqongopheleyo ze-PTEN zibonisa uvakalelo olukhulu kwiirapalogs.Kwimigca yeseli ye-PTEN-esilelayo ye-ccRCC, i-Rapalogs inqanda ukwanda kweeseli ngokubangela ukubanjwa kwe-G0 / G1 ngaphandle kokwenza i-apoptosis.Ukusebenzisa i-CRISPR/Cas9-generated isogenic cell lines, isifundo siqinisekise umbutho phakathi kokususwa kwe-PTEN kunye ne-Rapallo hypersensitivity.Ngokwahlukileyo, ukucinywa kwe-VHL okanye i-chromatin-modifying genes (PBRM1, SETD2, BAP1, okanye KDM5C) ayizange ichaphazele iimpendulo zeselula kwiirapalogs.I-Ectopic expression ye-activated mTOR mutant (C1483F) ibonakaliswe ukuchasana ne-PTEN-induced cell growth inhibition, ngelixa ukwaziswa kwe-drug-resistant mTOR mutant (A2034V) kwavumela iiseli ze-PTEN-ccRCC ezinqongopheleyo ukuba zibalekele iziphumo ezicindezelayo zokukhula kwe-rapalogs.Iiseli ze-PTEN ezinqongopheleyo ze-ccRCC zazinobuntununtunu ngakumbi kwiziphumo ezithintelayo ze-temsirolimus ekufudukeni kweeseli kunye nokukhula kwethumba kwi-zebrafish kunye neempuku ze-xenograft.Uphononongo lubonise ukuba ukucinywa kwe-PTEN kuhambelana novelwano lwe-rapallo kwaye ingasetyenziselwa njengophawu lokukhethwa kwe-rapallo therapy kwizigulane ze-ccRCC.
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
Isihloko senqaku: Indlela eguqukayo ye-microbiota yamanzi amdaka anetyuwa eninzi kunye negwele elinyamezela ityuwa kunye nokusetyenziswa kwayo.
I-DOI: 10.1016/j.jece.2022.107377
Ixesha lokukhutshwa: 2022-2-12
Iyunithi yombhali: Isikolo seSayensi zoBomi, iYunivesithi yaseJiangxi eqhelekileyo
Ushwankathelo: Amanzi amdaka endalo anetyuwa ephezulu ngamanzi amdaka avela kwimizi-mveliso anamalungu antsonkothileyo, ukuwohloka kwebhayoloji okulambathayo kunye nonyango olunzima lwebiochemical.Ukuze kubonakaliswe indlela yangaphakathi yoluntu lwe-microbial kunyango lwamanzi amdaka aphezulu anetyuwa ephilayo ngegwele elinyamezelayo ityuwa, izifundo zeempawu zoluntu lwe-microbial kunye nezinto zokusingqongileyo zenziwa.Amazinga okususwa kwemfuno ye-oksijini yeekhemikhali, i-NH3-H kunye ne-nitrogen epheleleyo yaphuculwa kakhulu kwi-pilot-scale WWTP.Iziphumo zolandelelwano oluphezulu zibonise ukuba i-biofortification ichaphazele kakhulu ubume be-microbial community.Kwinqanaba le-phylum, amaqela e-Proteobacteria kunye ne-Ascomycota ahamba phambili, ngelixa kwinqanaba le-genus i-Paracoccus kunye ne-Meyeroi amaqela ahamba phambili.I-Meyerella idlala indima ephambili kunyango lwamanzi amdaka anetyuwa eninzi, enokuba sesona sizathu siphuculweyo sokususa ungcoliseko.Ukongeza, i-pH, i-oksijini enyibilikileyo, kunye nomthamo ochaphazelayo zizinto eziphambili ezichaphazela ukulandelelana kweendawo ezincinci ze-microbial ngexesha le-bioaugmentation, nangona kunjalo, ubuninzi be-Meyerrotheca abuzange buchaphazeleke kukugxininiswa okungcolileyo.Olu phononongo lubonakalise ngokucwangcisiweyo utshintsho oluguquguqukayo kunye noqikelelo olusebenzayo lwe-microorganisms ngexesha le-bioaugmentation, kunye nobudlelwane phakathi koluntu lwe-microbial kunye nezinto zokusingqongileyo, ukubeka isiseko esiluqilima sethiyori sonyango olulandelayo lokuxinana okuphezulu kunye namanzi amdaka anetyuwa eninzi.
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
Isihloko seNqaku: Uhlalutyo lwe-Multi-Omics Emva koLawulo lwe-Vaginal ye- Bacteroides fragilis kwiiNkuku.
I-DOI: 10.3389/fmicb.2022.846011
Ixesha lokukhutshwa: 2022-2-16
Ubulungu boMbhali: ILabhoratri ePhambili yaseSichuan yezoLimo kunye neZilwanyana zoPhuhliso kunye nokuTshintsha
Abstract: Indawo yokuzala yenkukhu lilungu elibalulekileyo ekwenziweni kwamaqanda.Uqhagamshelwano olusondeleyo phakathi kwelungu lobufazi kunye nokusingqongileyo kwangaphandle kunokukhokelela ekuhlaselweni kweebhaktheriya ezahlukeneyo ze-pathogenic, ezichaphazela umgangatho wangaphakathi nangaphandle wamaqanda, kunye nokunyusa izinga lokufa kunye nokubangela ilahleko yezoqoqosho.Kwiminyaka yakutshanje, iiprobiotics ziye zazisa inzuzo yezoqoqosho kwimfuyo kunye nemveliso yeenkukhu njengenye indlela yokulwa ne-antibiotics.Imiphumo yokulawulwa kwe-vaginal ye-B. fragilis kwi-chicken cloacal microbiota, i-vaginal transcriptome kunye ne-metabolome yaphandwa ukuze kuhlolwe amandla okuxhamla kwi-B. fragilis.Iziphumo zibonise ukuba unyango lwe-B. fragilis luchaphazela ukubunjwa kwe-microbial ye-cloaca.Uhlalutyo lwe-Transcriptome lufumene ukuba i-immune-related genes CCN3, HAS2, kunye ne-RICTOR yayi-up-regulated, kunye ne-inflammation genenes EDNRB, TOX, kunye ne-NKX2-3 yayilawulwa phantsi, kwaye i-DEGs nayo yaphuculwa kulawulo lokuvuvukala, i-metabolism yeselula, kunye neendlela zokuphendula ze-synaptic.Ukongeza, i-metabolites eyahlukileyo yayinxulumene ikakhulu ne-steroid hormone biosynthesis, i-unsaturated fatty acid biosynthesis, kunye ne-arachidonic acid metabolism, kunye nezifundo ezichongiweyo unxulumano phakathi kwe-metabolites ekhethekileyo kunye nejene.Ekugqibeleni, olu phononongo lubonelela ngesiseko sethiyori sokusetyenziswa kweB. fragilis njengeprobiotic enokubakho kwimfuyo kunye nemveliso yeenkukhu.
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
I-RT Easy II (I-Master Premix ye-strand yokuqala ye-cDNA synthesis ye-qPCR)
Inombolo yekhathalogu: RT-01031
Inkcazo: 25 × 20 μL rxns
Isihloko senqaku: Ukwahluka kwemfuza ye-Echinococcus granulosus sensu lato eTshayina: Izifundo ze-Epidemiological kunye nophononongo olucwangcisiweyo
I-DOI: 10.1111/tbed.14469
Ixesha lokukhutshwa: 2022-2-9
Ubulungu boMbhali: ILabhoratri ePhambili yaseSichuan yezoLimo kunye neZilwanyana zoPhuhliso kunye nokuTshintsha
I-Cystic echinococcosis (CE) sisifo esingahoywayo se-tropical zoonotic esibangelwa yi-Echinococcus granulosus kwaye ihlala iyingxaki enkulu yempilo yoluntu yehlabathi.I-genotypes ekhoyo eyaziwayo ye-Echinococcus granulosus ngaphandle kwe-G4 ziye zachongwa e-China, ngakumbi i-Qinghai-Tibet Plateau, kwaye ukuhlukahluka kwabo kwemfuzo kuyingqayizivele kulo mmandla wehlabathi.Ngokophononongo olucwangcisiweyo, ukubunjwa kofuzo kwe-E. granulosa kwilizwe lam ngolu hlobo lulandelayo: E. granulosa (G1, G3), 98.3%;I-Echinococcus intermedius (G5), 0.1%;I-Echinococcus intermedius (G6, G7), 1.4%;kunye neCanada Echinococcus (G8, G10), 0.2%.Ngokukodwa, izinga losulelo lwe-G1 lalingama-97.7% kwaye liphawulwe luluhlu olubanzi lwabamkeli kunye nokusabalalisa ngokwejografi.Iziphumo ze-epidemiological zibonise ukwakheka kofuzo lwe-E. coli oluzinzileyo nolucolekileyo kwiigusha kunye ne-yak ukusuka kumaphondo amathathu e-CE axhaphakileyo (i-Xinjiang, i-Sichuan, ne-Qinghai).Iigusha (287/406, 70.7%) zinezinga eliphezulu lamaqhuqhuva achumileyo kuneyak (28/184, 15.2%).Kwiminyaka engama-29 edlulileyo, bekukho ama-51 e-Echinococcus granulosus cox1 haplotypes e-China.I-haplotype ye-ancestral (Hap_2) yahlala iyi-haplotype eqhelekileyo, i-12 i-haplotypes eqhelekileyo yayiyi-endemic, kwaye i-9 ye-haplotypes esanda kuxelwa yachongwa ngexesha lophando.Iziphumo zicebisa ukuba ugonyo olusisinyanzelo lweegusha kunye nephulo lokulinga ugonyo lwe-EG95 lwe-yaks luhambelana ngokusondeleyo nemo yangoku ye-genotype.
I-Foregene
Iimveliso ezikhankanyiweyo zoncwadi
Qhagamshelana:
Maggie |Uphuhliso lwamashishini
IForegene Co., Ltd
M: +86-15281067355
URL: www.foreivd.com
Ixesha lokuposa: Apr-08-2022
